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Recent advances in psoriasis with special reference to pathophysiology and therapeutics
https://kindai.repo.nii.ac.jp/records/10494
https://kindai.repo.nii.ac.jp/records/10494ecb238ab-e7b4-4cee-af3d-da2bef59b52e
| 名前 / ファイル | ライセンス | アクション |
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AA0050842X-20090600-0015.pdf (2.7 MB)
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| Item type | ☆紀要論文 / Departmental Bulletin Paper(1) | |||||||||||||
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| 公開日 | 2010-06-09 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | Recent advances in psoriasis with special reference to pathophysiology and therapeutics | |||||||||||||
| 言語 | en | |||||||||||||
| 著者 |
Kawara, Shigeru
× Kawara, Shigeru
× Kawada, Akira
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| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
| キーワード | ||||||||||||||
| 主題 | psoriasis, pathophysiology, therapy, biologics | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
| 資源タイプ | departmental bulletin paper | |||||||||||||
| 著者所属(翻訳) | ||||||||||||||
| 値 | Department of Dermatology, Kinki University School of Medicine | |||||||||||||
| 著者所属(翻訳) | ||||||||||||||
| 値 | Department of Dermatology, Kinki University School of Medicine | |||||||||||||
| 版 | ||||||||||||||
| 出版タイプ | NA | |||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_be7fb7dd8ff6fe43 | |||||||||||||
| 出版者 名前 | ||||||||||||||
| 出版者 | The Kinki University Medical Association | |||||||||||||
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY 巻 34, 号 1, p. 15-25, 発行日 2009-06-01 |
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| ISSN | ||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||
| 収録物識別子 | 03866092 | |||||||||||||
| 抄録 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | Psoriasis is an important inflammatory disease in the dermatological field. It is characterized with erythematous plaque with thick scales clinically and epidermal thickening and perivascular lymphocyte infiltration histopathologically. Although pathogenesis of psoriasis has not been elucidated fully, abnormalities both in T-cell mediated immunity and keratinization have been addressed. Various cytokines, chemokines, angiogenic factors released from epidermal keratinocytes may affect the innate and acquired immune systems. Interferon α, tumor necrosis factor α(TNF α), interleukin-2 (IL-2), IL-12 and IL-23 have been revealed to be key factors in pathogenesis of psoriasis, a Thl-dominant disease. Then, new biologic drugs targeting these cytokines have been developed recently as T-cell agents, anti-TNF agents and anti-IL-12 and IL-23 agents. This comprehensive review focuses recent findings in pathophysiology of psoriasis and development of new therapeutic modalities with special reference to novel biologics. | |||||||||||||
| フォーマット | ||||||||||||||
| 内容記述タイプ | Other | |||||||||||||
| 内容記述 | application/pdf | |||||||||||||
