{"created":"2023-06-20T16:40:07.226714+00:00","id":10292,"links":{},"metadata":{"_buckets":{"deposit":"053fa0dd-3f80-4ee0-a897-a96c9c96282a"},"_deposit":{"created_by":3,"id":"10292","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"10292"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00010292","sets":["14:923:1477:1499","21:3039:3456:3466"]},"author_link":["19486","19485","19487"],"item_2_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-12-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3-4","bibliographicPageEnd":"166","bibliographicPageStart":"157","bibliographicVolumeNumber":"35","bibliographic_titles":[{"bibliographic_title":"近畿大学医学雑誌"},{"bibliographic_title":"Medical journal of Kinki University","bibliographic_titleLang":"en"}]}]},"item_2_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"[抄録] 脳卒中易発症性高血圧自然発症ラット（SHRSP）の食塩負荷による腎障害に対してトロンボキサンA_2/プロスタグランジンH_2受容体（TPR）拮抗薬であるONO-8809の腎保護作用を検討した．６週齢の雄性SHRSP/Kpoを通常食群（n＝9），高食塩群（２％ NaCl，n＝10），高食塩・薬物投与群（２％ NaCl＋0.6mg/kg/day ONO-8809，n＝10）の３群に分け，８週間経口投与を行い，血圧および腎機能評価（組織学的，免疫組織学的検討）をおこなった．血圧は３群共に有意差が無かったが，通常食群に比べ高食塩群では腎機能の悪化，腎組織での糸球体の硬化，細動脈の増殖，壊死像や線維化が見られたが，薬物投与群でそれらは改善した．免疫組織学的検討では高食塩群で糸球体や尿細管間質，特に血管周囲にマクロファージの浸潤，MCP1，ニトロチロシンの発現がみられ，それをONO-8809は改善した．食塩負荷により血圧非依存性に炎症反応が起こり，TPRを介して腎障害をきたし，細動脈で炎症細胞の浸潤がみられたが，これらをTPR拮抗薬のONO-8809が改善した．したがって，食塩負荷SHRSPの腎臓では血圧非依存性にTXA_2を介した炎症が腎機能や腎組織の悪化に関与していたと推測でき，これをTPR拮抗薬が改善させた．","subitem_description_type":"Abstract"}]},"item_2_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学医学会"}]},"item_2_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03858367","subitem_source_identifier_type":"ISSN"}]},"item_2_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部薬理学教室"},{"subitem_text_value":"近畿大学医学部薬理学教室"},{"subitem_text_value":"近畿大学医学部薬理学教室"}]},"item_2_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"永谷,  裕介"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"大島,  佳奈"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"東野,  英明"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-18"}],"displaytype":"detail","filename":"AN00063584-20101225-0157.pdf","filesize":[{"value":"8.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AN00063584-20101225-0157.pdf","url":"https://kindai.repo.nii.ac.jp/record/10292/files/AN00063584-20101225-0157.pdf"},"version_id":"42142845-f6b1-43b8-a090-10c67909936e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"SHRSP","subitem_subject_scheme":"Other"},{"subitem_subject":"TXA_2","subitem_subject_scheme":"Other"},{"subitem_subject":"TPR","subitem_subject_scheme":"Other"},{"subitem_subject":"食塩感受性腎障害","subitem_subject_scheme":"Other"},{"subitem_subject":"MCP1","subitem_subject_scheme":"Other"},{"subitem_subject":"炎症","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"〈原著〉脳卒中易発症性高血圧自然発症ラット（SHRSP）の食塩負荷による腎障害に対するトロンボキサンA_2受容体拮抗薬の腎保護作用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"〈原著〉脳卒中易発症性高血圧自然発症ラット（SHRSP）の食塩負荷による腎障害に対するトロンボキサンA_2受容体拮抗薬の腎保護作用"}]},"item_type_id":"2","owner":"3","path":["1499","3466"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-01-31"},"publish_date":"2012-01-31","publish_status":"0","recid":"10292","relation_version_is_last":true,"title":["〈原著〉脳卒中易発症性高血圧自然発症ラット（SHRSP）の食塩負荷による腎障害に対するトロンボキサンA_2受容体拮抗薬の腎保護作用"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-20T23:43:19.633784+00:00"}