{"created":"2023-06-20T16:40:02.426355+00:00","id":10206,"links":{},"metadata":{"_buckets":{"deposit":"a4a175d2-0f73-4123-bbed-e583aac8af7a"},"_deposit":{"created_by":3,"id":"10206","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"10206"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00010206","sets":["14:923:1477:1509","21:3039:3456:3460"]},"author_link":["19198","19199","19196","19200","19197","19192","19189","19193","19195","19201","19194","19191","19190"],"item_2_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-06-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"122","bibliographicPageStart":"113","bibliographicVolumeNumber":"34","bibliographic_titles":[{"bibliographic_title":"近畿大学医学雑誌"},{"bibliographic_title":"Medical journal of Kinki University","bibliographic_titleLang":"en"}]}]},"item_2_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"[抄録] [目的]食道癌根治的化学放射線療法(CRT)後遺残・再発腫瘍の特性を臨床病理学的に検討する. [対象] salvage 　(S)　群28例，術前無治療　(U)　群31例． [方法]　免疫染色(HIF-1α，GLUT-1， VEGF， CD34， CD105， Ki-67，E-Cadherin ；E -CD) ，および形態学的検討. [結果]　細胞活性(Ki-67)および浸潤能(E-CD)に差は認めなかった(p＝0.89，p＝0.38). S群では腫瘍密度の減少を認めた(p＜0.001).　低酸素の指標であるHIF-1α およびGLUT-1，血管新生促進因子のVEGFではS群で発現亢進を認めた(p＜0.001，p＜0.005， p＜0.001). CD34による微小血管密度(MVD)では両群間に差は認めなかったが(p＝0.19)，腫瘍増殖に特異的なCD105のMVDではS群の新生血管の減少を認めた(p＜0.001).腫瘍潰瘍底の深さはS群が深かった(p＜0.001). [考察]　根治的CRT後遺残・再発腫瘍は，増殖・浸潤能は術前未治療群と同等だが， HIF-1α， GLUT-1， VEGFの発現増強によりCRT後の低酸素環境へ適応し増殖する.しかし血管新生は抑制され，食道壁内の遺残細胞は内部壊死を伴って深い潰瘍を形成し，潰瘍底である先進部を中心に増殖することで容易に周囲へ浸潤・穿孔し，高い悪性度を示すと考えられた.","subitem_description_type":"Abstract"}]},"item_2_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学医学会"}]},"item_2_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03858367","subitem_source_identifier_type":"ISSN"}]},"item_2_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部外科学教室"},{"subitem_text_value":"近畿大学医学部外科学教室"},{"subitem_text_value":"近畿大学医学部外科学教室: 近畿大学医学部附属病院通院治療センター"},{"subitem_text_value":"近畿大学医学部外科学教室"},{"subitem_text_value":"近畿大学医学部外科学教室"},{"subitem_text_value":"近畿大学医学部外科学教室"},{"subitem_text_value":"近畿大学医学部外科学教室"},{"subitem_text_value":"近畿大学医学部外科学教室"},{"subitem_text_value":"近畿大学医学部外科学教室"},{"subitem_text_value":"近畿大学医学部外科学教室"},{"subitem_text_value":"近畿大学医学部外科学教室"},{"subitem_text_value":"近畿大学医学部外科学教室"},{"subitem_text_value":"近畿大学医学部外科学教室"}]},"item_2_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"岩間,  秘"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"安田,  卓司"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"今野,  元博"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"中森,  康浩"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"西山,  厚子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"武本,  智樹"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"白石,  治"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"安田,  篤"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"彭,  英峰"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"新海,  政幸"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"平井,  紀彦"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"今本,  治彦"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"塩﨑,  均"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-18"}],"displaytype":"detail","filename":"AN00063584-20090625-0113.pdf","filesize":[{"value":"2.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AN00063584-20090625-0113.pdf","url":"https://kindai.repo.nii.ac.jp/record/10206/files/AN00063584-20090625-0113.pdf"},"version_id":"4b52a79c-c221-4544-805a-c1c7ce2f4724"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"食道癌","subitem_subject_scheme":"Other"},{"subitem_subject":"根治的化学放射線療法(CRT)","subitem_subject_scheme":"Other"},{"subitem_subject":"salvage手術","subitem_subject_scheme":"Other"},{"subitem_subject":"遺残・再発腫瘍","subitem_subject_scheme":"Other"},{"subitem_subject":"GLUT-1","subitem_subject_scheme":"Other"},{"subitem_subject":"HIF-1α","subitem_subject_scheme":"Other"},{"subitem_subject":"VEGF","subitem_subject_scheme":"Other"},{"subitem_subject":"CD34","subitem_subject_scheme":"Other"},{"subitem_subject":"CD105","subitem_subject_scheme":"Other"},{"subitem_subject":"Ki-67","subitem_subject_scheme":"Other"},{"subitem_subject":"E-Cadherin","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"〈原著〉食道癌根治的化学放射線療法（CPT）後遺残・再発腫瘍に関する臨床病理学的検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"〈原著〉食道癌根治的化学放射線療法（CPT）後遺残・再発腫瘍に関する臨床病理学的検討"}]},"item_type_id":"2","owner":"3","path":["1509","3460"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-01-31"},"publish_date":"2012-01-31","publish_status":"0","recid":"10206","relation_version_is_last":true,"title":["〈原著〉食道癌根治的化学放射線療法（CPT）後遺残・再発腫瘍に関する臨床病理学的検討"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T19:28:50.043126+00:00"}