{"created":"2023-06-20T16:40:00.504452+00:00","id":10170,"links":{},"metadata":{"_buckets":{"deposit":"991b44b1-edd8-4ae8-ba46-adf38af89280"},"_deposit":{"created_by":3,"id":"10170","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"10170"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00010170","sets":["14:923:1477:1505","21:3039:3456:3458"]},"author_link":["19065","19067","19071","19072","19075","19066","19069","19068","19070","19074","19077","19064","19076","19063","19073"],"item_2_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-12-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"228","bibliographicPageStart":"223","bibliographicVolumeNumber":"34","bibliographic_titles":[{"bibliographic_title":"近畿大学医学雑誌"},{"bibliographic_title":"Medical journal of Kinki University","bibliographic_titleLang":"en"}]}]},"item_2_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"[抄録] 目的：自己免疫性甲状腺疾患（AITD）患者における膵島自己免疫の実態を明らかにする．方法：AITD 患者866人（バセドウ病患者546人，橋本病患者320人）と非自己免疫性甲状腺疾患患者221人を対象にGAD 抗体陽性率と抗体価を比較するとともに，抗体陽性AITD 患者の臨床的特徴及びHLA-DRB1，DQB1 とCTLA4 の遺伝子型を陰性者と比較．成績：GAD 抗体陽性率はAITD 患者で対照者に比し有意に高率（5.8％ vs. 0.6％，P＜0.001）．糖尿病有病率はGAD 抗体陽性者において陰性者に比し有意に高率（40.0％ vs. 10.1％，p＜0.0001），陽性者の中では高抗体価群で低抗体価群に比し有意に高率（64％ vs. 16％，p＝0.001）．GAD 抗体陽性AITD 患者は陰性患者に比し，糖尿病発症年齢が有意に若く，BMIが有意に低く，HbA1c値，インスリン使用率が有意に高値．DRB1＊0405-DQB1＊0401ハプロタイプはGAD 抗体陽性AITD 患者で抗体陰性者，対照者に比し有意に高頻度．CTLA4 の6230G＞A 多型（rs3087243）はAITD と有意の関連を示したが，GAD 抗体の有無とは関連を認めなかった．結論：AITD 患者ではGAD 抗体が高率に陽性を示し，抗体陽性者は１型糖尿病の臨床的，遺伝的特徴を有することが示された．","subitem_description_type":"Abstract"}]},"item_2_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学医学会"}]},"item_2_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03858367","subitem_source_identifier_type":"ISSN"}]},"item_2_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部内科学教室（内分泌・代謝・糖尿病内科部門）"},{"subitem_text_value":"近畿大学医学部内科学教室（内分泌・代謝・糖尿病内科部門）"},{"subitem_text_value":"近畿大学医学部内科学教室（内分泌・代謝・糖尿病内科部門）"},{"subitem_text_value":"近畿大学医学部内科学教室（内分泌・代謝・糖尿病内科部門）"},{"subitem_text_value":"近畿大学医学部内科学教室（内分泌・代謝・糖尿病内科部門）"},{"subitem_text_value":"近畿大学医学部内科学教室（内分泌・代謝・糖尿病内科部門）"},{"subitem_text_value":"近畿大学医学部内科学教室（内分泌・代謝・糖尿病内科部門）"},{"subitem_text_value":"近畿大学医学部内科学教室（内分泌・代謝・糖尿病内科部門）"},{"subitem_text_value":"近畿大学医学部内科学教室（内分泌・代謝・糖尿病内科部門）"},{"subitem_text_value":"近畿大学医学部内科学教室（内分泌・代謝・糖尿病内科部門）"},{"subitem_text_value":"近畿大学医学部内科学教室（内分泌・代謝・糖尿病内科部門）"},{"subitem_text_value":"近畿大学医学部内科学教室（内分泌・代謝・糖尿病内科部門）"},{"subitem_text_value":"近畿大学医学部内科学教室（内分泌・代謝・糖尿病内科部門）"},{"subitem_text_value":"近畿大学医学部内科学教室（内分泌・代謝・糖尿病内科部門）"},{"subitem_text_value":"近畿大学医学部内科学教室（内分泌・代謝・糖尿病内科部門）"}]},"item_2_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"守口,  将典"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"能宗,  伸輔"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"川畑,  由美子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"山内,  孝哲"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"原田,  剛史"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"小牧,  克守"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"馬場谷,  成"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"廣峰,  義久"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"伊藤,  裕進"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"村田,  佳織"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"山片,  里美"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"東本,  貴弘"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"朴,  忠勇"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"大野,  恭裕"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"池上,  博司"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-18"}],"displaytype":"detail","filename":"AN00063584-20091225-0223.pdf","filesize":[{"value":"358.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AN00063584-20091225-0223.pdf","url":"https://kindai.repo.nii.ac.jp/record/10170/files/AN00063584-20091225-0223.pdf"},"version_id":"e6d1fd4f-e71f-4094-87bb-01666ef93bde"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"自己免疫性甲状腺疾患","subitem_subject_scheme":"Other"},{"subitem_subject":"バセドウ病","subitem_subject_scheme":"Other"},{"subitem_subject":"橋本病","subitem_subject_scheme":"Other"},{"subitem_subject":"GAD抗体","subitem_subject_scheme":"Other"},{"subitem_subject":"一塩基多型","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝子","subitem_subject_scheme":"Other"},{"subitem_subject":"HLA","subitem_subject_scheme":"Other"},{"subitem_subject":"CTLA4","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"〈原著〉自己免疫性甲状腺疾患患者における膵島自己免疫に関する臨床的・遺伝的研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"〈原著〉自己免疫性甲状腺疾患患者における膵島自己免疫に関する臨床的・遺伝的研究"}]},"item_type_id":"2","owner":"3","path":["1505","3458"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-01-31"},"publish_date":"2012-01-31","publish_status":"0","recid":"10170","relation_version_is_last":true,"title":["〈原著〉自己免疫性甲状腺疾患患者における膵島自己免疫に関する臨床的・遺伝的研究"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-20T23:45:42.039021+00:00"}