{"created":"2023-06-20T16:39:52.398951+00:00","id":10008,"links":{},"metadata":{"_buckets":{"deposit":"a89df9e3-4d04-43f5-9ec6-784525eaee8d"},"_deposit":{"created_by":3,"id":"10008","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"10008"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00010008","sets":["14:923:2219:2233","21:3039:3435:3437"]},"author_link":["18365","18364","18368","18366","18369","18367","18363"],"item_2_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Effect of hypoxia on early germ cell differentiation from a mouse embryonic stem cell line."}]},"item_2_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-03-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"14","bibliographicPageEnd":"57","bibliographicPageStart":"49","bibliographic_titles":[{"bibliographic_title":"近畿大学先端技術総合研究所紀要"},{"bibliographic_title":"Memoirs of Institute of Advanced Technology, Kinki University","bibliographic_titleLang":"en"}]}]},"item_2_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"酸素濃度は、細胞の様々な生理的状態、遺伝子発現状態に影響を与え、初期発生とも深く関わっていることが知られている。酸素の濃度依存的に様々な遺伝子の発現を調節する転写因子としてHypoxia Inducible Factor (HIF) ファミリーの存在が知られており、中でもHIF-1α 、2α が多くの遺伝子の転写調節を行っていることが報告されている。近年、HIFファミリーの発現が初期の生殖細胞発生に重要な役割を持っていることが示唆されているが、主体となっている分子とその機能は明らかとなっていない。本研究では、マウスES細胞を材料に、低酸素環境下における生殖細胞発生関連遺伝子(Blimp1、Stella、MVH)の発現変化を観察した。また、通常酸素濃度でHIFを誘導するDeferoxamine mesylate (DFO)を添加し、その結果を比較する事で、HIF遺伝子が生殖細胞分化に与える影響について検討を行った。","subitem_description_type":"Abstract"}]},"item_2_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学先端技術総合研究所"}]},"item_2_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13468693","subitem_source_identifier_type":"ISSN"}]},"item_2_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Mihara, Toshihiro"},{"subitem_text_language":"en","subitem_text_value":"Hayashiji, Nozomi"},{"subitem_text_language":"en","subitem_text_value":"Teramura, Takeshi"},{"subitem_text_language":"en","subitem_text_value":"Onodera, Yuta"},{"subitem_text_language":"en","subitem_text_value":"Matsuoka, Toshiki"},{"subitem_text_language":"en","subitem_text_value":"Fukuda, Kanji"},{"subitem_text_language":"en","subitem_text_value":"Hosoi, Yoshihiko"}]},"item_2_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学大学院生物理工学研究科生物工学専攻:近畿大学医学部附属病院高度先端総合医療センター/再生医療部門"},{"subitem_text_value":"近畿大学生物理工学部遺伝子工学科"},{"subitem_text_value":"近畿大学医学部附属病院高度先端総合医療センター/再生医療部門"},{"subitem_text_value":"近畿大学医学部附属病院高度先端総合医療センター/再生医療部門"},{"subitem_text_value":"近畿大学医学部リハビリテーション科"},{"subitem_text_value":"近畿大学医学部附属病院高度先端総合医療センター/再生医療部門:近畿大学医学部リハビリテーション科"},{"subitem_text_value":"近畿大学大学院生物理工学研究科生物工学専攻:近畿大学生物理工学部遺伝子工学科"}]},"item_2_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Graduate School of Biology-Oriented Science and Technology, Kinki University , Institute of Advanced Clinical Medicine, Kinki University School of Medicine"},{"subitem_text_value":"Department of Biology-Oriented Science and Technology, Kinki University"},{"subitem_text_value":"Institute of Advanced Clinical Medicine, Kinki University School of Medicine"},{"subitem_text_value":"Institute of Advanced Clinical Medicine, Kinki University School of Medicine"},{"subitem_text_value":"Department of Orthopaedic Surgely, Kinki University School of Medicine"},{"subitem_text_value":"Institute of Advanced Clinical Medicine, Kinki University School of Medicine , Department of Orthopaedic Surgely, Kinki University School of Medicine"},{"subitem_text_value":"Graduate School of Biology-Oriented Science and Technology, Kinki University , Department of Biology-Oriented Science and Technology, Kinki University"}]},"item_2_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"三原,  敏敬"},{"creatorName":"ミハラ, トシヒロ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"林地,  のぞみ"},{"creatorName":"ハヤシジ, ノゾミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"寺村,  岳士"},{"creatorName":"テラムラ, タケシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"小野寺,  勇太"},{"creatorName":"オノデラ, ユウタ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"松岡,  俊樹"},{"creatorName":"マツオカ, トシキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"福田,  寛二"},{"creatorName":"フクダ, カンジ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"細井,  美彦"},{"creatorName":"ホソイ, ヨシヒコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-18"}],"displaytype":"detail","filename":"AA11574630-20090331-0049.pdf","filesize":[{"value":"1.1 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