2026-03-05T08:00:37Z https://kindai.repo.nii.ac.jp/oai

oai:kindai.repo.nii.ac.jp:00002139 2023-06-21T02:15:35Z 14:2529:2619:2635 21:2532:2621:2636

Morphological and biochemical studies on pathogenesis of vascular changes in transarterial infusion of anti-cancer drugs 抗癌剤動注による動脈病変の発生機序に関する形態学的および生化学的研究 岡藤, 龍正 オカフジ, タツマサ transarterial infusion cisplatin artery free radical superoxide dismutase vitamin E [ABSTRACT] To elucidate the pathogenesis of vascular changes caused by transarterial infusion of anti-cancer drugs, the rat hepatic artery and mesenteric artery were examined morphologically and biochemically after cisplatin-lipiodol infusion. Severe degenerative changes were found in endothelial cells as well as medial smooth muscle cells in hepatic and mesenteric arteries. Such changes were milder in the artery in the group administered cisplatinlipiodol and vitamin E (vitamin E group) than in the group administered cisplatin-lipiodol ( cisplatin group) . Superoxide dismutase, a superoxide anion scavenger, was higher in the vitamin E group than in the cisplatin group. Furthermore, Na/K-ATPase, a membrane-related enzyme, was also higher in the vitamin E group. These findings indicate that induced arterial changes were caused by lipid-peroxidation radicals and thus prevented by vitamin E administration. 学位の種類：医学　　学位授与年月日：1994/3/24　　指導：石田, 修 教授(Director: Prof. Ishida, Osamu)　　報告番号：甲第292号　　学内授与番号：医甲239　　NDL書誌ID：000000278333 application/pdf thesis 近畿大学 1994-03-01 VoR application/pdf 博士学位論文 1 25 Thesis or Dissertation https://kindai.repo.nii.ac.jp/record/2139/files/Thesis_Mek0239-19940324-0001.pdf https://kindai.repo.nii.ac.jp/records/2139 jpn