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ステージIII大腸癌の再発予防におけるペプチドワクチン療法の優勢性に関する研究
https://kindai.repo.nii.ac.jp/records/19751
https://kindai.repo.nii.ac.jp/records/1975156ac6669-00bb-498d-b9e4-6b97c32bc2d3
名前 / ファイル | ライセンス | アクション |
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15K10153seika.pdf (321.3 kB)
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Item type | 研究報告書 / Research Paper(1) | |||||
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公開日 | 2018-11-20 | |||||
タイトル | ||||||
タイトル | ステージIII大腸癌の再発予防におけるペプチドワクチン療法の優勢性に関する研究 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Clinical trial of peptide vaccination with oral chemotherapy following curative resection for stage III colorectal cancer | |||||
著者 |
川村, 純一郎
× 川村, 純一郎× 杉浦, 史哲× 奥野, 清隆 |
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言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題 | 大腸癌, ペプチドワクチン, 術後補助療法, CTL反応, 細胞障害性T細胞 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
著者(英) | ||||||
en | ||||||
KAWAMURA, Junichiro | ||||||
著者(英) | ||||||
en | ||||||
SUGIURA, Fumiaki | ||||||
著者(英) | ||||||
en | ||||||
OKUNO, Kiyotaka | ||||||
著者 所属 | ||||||
近畿大学医学部; 講師 | ||||||
著者 所属 | ||||||
近畿大学医学部; 講師 | ||||||
著者 所属 | ||||||
近畿大学医学部; 教授 | ||||||
著者所属(翻訳) | ||||||
Kindai University | ||||||
著者所属(翻訳) | ||||||
Kindai University | ||||||
著者所属(翻訳) | ||||||
Kindai University | ||||||
著者 役割 | ||||||
研究代表者/研究分担者/研究分担者 | ||||||
著者 外部リンク | ||||||
関連名称 | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K10153/ | |||||
版 | ||||||
出版タイプ | NA | |||||
出版タイプResource | http://purl.org/coar/version/c_be7fb7dd8ff6fe43 | |||||
出版者 名前 | ||||||
出版者 | 近畿大学 | |||||
書誌情報 |
科学研究費助成事業研究成果報告書 (2017) p. 1-4, 発行日 2018 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 研究成果の概要(和文):StageIII大腸癌根治術患者に対する経口抗がん剤(UFT/LV)併用ペプチドワクチン療法の臨床的有効性、安全性を検証する第2相臨床研究を行った。主要評価項目である無再発生存期間(RFS)は、HLA-A24陽性・陰性群で有意差を認めなかったが、細胞障害性T細胞(CTL)反応陽性群で有意に予後良好との結果を得た。ペプチドワクチン投与後のCTL反応は、治療効果を予測する良い指標になりうる 研究成果の概要(英文):We conducted a phase II clinical trial involving patients with stage III CRC. All enrolled patients whose human leukocyte antigen (HLA)-A status was double-blinded were administered the same regime of a peptide vaccine and UFT/LV chemotherapy. The primary objective of the study was the comparison of relapse-free survival (RFS) in patients with HLA-A*2402 versus those without HLA-A*2402. A total of 46 patients were enrolled in the study. Three-year RFS was not significantly different between HLA-A*2402 matched and unmatched groups. Three-year RFS was significantly better in patients with positive CTL responses in the HLA-A*2402 matched group compared with those without. In conclusion, vaccination-induced immune responses combined with UFT/LV are positively associated with survival benefit in patients with HLA-A* 2402-positive stage III CRC. |
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内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 研究種目:基盤研究(C); 研究期間:2015~2017; 課題番号:15K10153; 研究分野:消化器外科; 科研費の分科・細目: | |||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | Research Paper | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf |