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リプログラミングにおけるヒストン脱アセチル化酵素の標的タンパク質に関する考察
https://kindai.repo.nii.ac.jp/records/9993
https://kindai.repo.nii.ac.jp/records/9993d589cb63-d5d8-4850-a618-64223e3e8119
名前 / ファイル | ライセンス | アクション |
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AA11574630-20100331-0001.pdf (1.3 MB)
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Item type | ☆紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2010-06-10 | |||||
タイトル | ||||||
タイトル | リプログラミングにおけるヒストン脱アセチル化酵素の標的タンパク質に関する考察 | |||||
その他(別言語等)のタイトル | ||||||
その他のタイトル | The discussion on the target protein of histone deacetylase for reprogramming. | |||||
著者 |
松原, 圭吾
× 松原, 圭吾× 鎌田, 悠× 孫谷, 匡輝× Lee, Ah, Reum× 矢持, 隆之× 佐伯, 和弘× 松本, 和也× 岸上, 哲士× 入谷, 明× 細井, 美彦 |
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言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者(英) | ||||||
en | ||||||
Matsubara, Keigo | ||||||
著者(英) | ||||||
en | ||||||
Kamata, Yu | ||||||
著者(英) | ||||||
en | ||||||
Magotani, Masateru | ||||||
著者(英) | ||||||
en | ||||||
著者(英) | ||||||
en | ||||||
Yamochi, Takayuki | ||||||
著者(英) | ||||||
en | ||||||
Saeki, Kazuhiro | ||||||
著者(英) | ||||||
en | ||||||
Matsumoto, Kazuya | ||||||
著者(英) | ||||||
en | ||||||
Kishigami, Satoshi | ||||||
著者(英) | ||||||
en | ||||||
Iritani, Akira | ||||||
著者(英) | ||||||
en | ||||||
Hosoi, Yoshihiko | ||||||
著者 所属 | ||||||
近畿大学大学院生物理工学研究科 | ||||||
著者 所属 | ||||||
近畿大学生物理工学部 遺伝子工学科 | ||||||
著者 所属 | ||||||
近畿大学生物理工学部 遺伝子工学科 | ||||||
著者 所属 | ||||||
理化学研究所発生・再生科学総合研究センター | ||||||
著者 所属 | ||||||
近畿大学大学院生物理工学研究科 | ||||||
著者 所属 | ||||||
近畿大学生物理工学部 遺伝子工学科 | ||||||
著者 所属 | ||||||
近畿大学生物理工学部 遺伝子工学科 | ||||||
著者 所属 | ||||||
近畿大学生物理工学部 遺伝子工学科 | ||||||
著者 所属 | ||||||
近畿大学生物理工学部 遺伝子工学科 | ||||||
著者 所属 | ||||||
近畿大学生物理工学部 遺伝子工学科 | ||||||
著者所属(翻訳) | ||||||
Graduate School of Biology-Oriented Science and Technology, Kinki University | ||||||
著者所属(翻訳) | ||||||
Department of Genetic Engineering, Kinki University | ||||||
著者所属(翻訳) | ||||||
Department of Genetic Engineering, Kinki University | ||||||
著者所属(翻訳) | ||||||
RIKEN, Center for Developmental Biology | ||||||
著者所属(翻訳) | ||||||
Graduate School of Biology-Oriented Science and Technology, Kinki University | ||||||
著者所属(翻訳) | ||||||
Department of Genetic Engineering, Kinki University | ||||||
著者所属(翻訳) | ||||||
Department of Genetic Engineering, Kinki University | ||||||
著者所属(翻訳) | ||||||
Department of Genetic Engineering, Kinki University | ||||||
著者所属(翻訳) | ||||||
Department of Genetic Engineering, Kinki University | ||||||
著者所属(翻訳) | ||||||
Department of Genetic Engineering, Kinki University | ||||||
版 | ||||||
出版タイプ | NA | |||||
出版タイプResource | http://purl.org/coar/version/c_be7fb7dd8ff6fe43 | |||||
出版者 名前 | ||||||
出版者 | 近畿大学先端技術総合研究所 | |||||
書誌情報 |
Memoirs of Institute of Advanced Technology, Kinki University en : 近畿大学先端技術総合研究所紀要 号 15, p. 1-7, 発行日 2010-03-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13468693 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Somatic cell nuclear transfer technology enables somatic cells to achieve totipotency. In addition, pluripotency is acquired by introduction of only four transcriptional factors(Oct3/4, Sox2, Klf4, c-Myc) into somatic cells using iPS cell technology. However, one of the problems in these technologies is low efficiency of reprogramming. In previous studies, it was reported that the efficiency of reprogramming improved by histone deacetylase inhibitor (HDACi) treatment, but little is known of the molecular mechanism. The facilitation of histone acetylation by HDACi treatment relates to an increase in gene expression, and HDACi treatment also facilitates acetylation of non-histone proteins, and affects physiological activation. Thus, it is suggested that the acetylation of non-histone proteins relates to improvement of the reprogramming efficiency. In this review, we outline the mechanism of acetylation of non-histone proteins, and extract non-histone proteins possibly related to improving reprogramming fromGEO database. | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf |