Department of Developmental Biology, Faculty of Medicine, Shimane University
Department of Developmental Biology, Faculty of Medicine, Shimane University
Department of Developmental Biology, Faculty of Medicine, Shimane University
Department of Developmental Biology, Faculty of Medicine, Shimane University
Department of Developmental Biology, Faculty of Medicine, Shimane University
Department of Biotechnology and Chemistry, Faculty of Engineering, Kinki University
Department of Developmental Biology, Faculty of Medicine, Shimane University
版
publisher
出版者 名前
近畿大学工学部研究報告
出版社 カナ
キンキ ダイガク コウガクブ ケンキュウ ホウコク
出版社 ローマ字
Kinki daigaku kogakubu kenkyu hokokusho
出版年(from)
2014
出版年(to)
12-20
日付 作成日
2015-01-22
雑誌名
近畿大学工学部研究報告
雑誌名(英)
Research reports of the Faculty of Engineering, Kinki University
号
48
ページ
13 - 17
発行年
2014-12-01
ISSN
0386491X
抄録
[Abstract] Shiikuwasha (Citrus depressa Hayata), a typical Japanese citrus fruit, recently has been expected to make the healthy skin. Nobiletin (5, 6, 7, 8, 3', 4'-hexamethoxy flavone), a citrus polymethoxy flavonoid, is one of the compounds of Shiikuwasha. Nobiletin has been reported in in vitro studies that it possesses various bioactive effects, such as anti-inflammatory activities, however, few in vivo studies have been done. In this study, we examined the effects of nobiletin involved in the impact on the collagenolysis. We revealed that nobiletin increases mRNA expressions of anti-oxidant enzymes. Furthermore, nobiletin suppresses mRNA expressions of matrix metalloproteinases (MMPs) and increases mRNA expressions of peroxisome proliferator activated receptors (PPARs). These results suggest that anti-oxidative action and suppression of the collagenolysis in the dermis may be enhanced through the oral administration of nobiletin.
<研究論文>合成ノビレチンの経口投与によるラット真皮への影響
AN00063799-20141220-0013.pdf
(1.75MB)
