Graduate School of Systems Engineering, Kinki University
Konan Chemical Industry CO.,Ltd
Kobe Koryo Co., Ltd
Department of Pharmaceutical Health Care and Life Sciences, Nihon Pharmaceutical University
Joint Research Center, Kinki University
Department of Biotechnology and Chemistry, Faculty of Engineering, Kinki University
Department of Biotechnology and Chemistry, Faculty of Engineering, Kinki University
Department of Biotechnology and Chemistry, Faculty of Engineering, Kinki University
Research reports of the Faculty of Engineering, Kinki University
巻
46
ページ
7 - 13
発行年
2012-12-01
ISSN
0386491X
抄録
[SUMMARY] For ensuring useful materials including pharmaceutical compounds, it is important to extract and separate the underlying leading compounds from natural products such as plants, and to characterize their structure and pharmacological activity. Kaempferol (1), quercetin (2), quercitrin (3), rutin (4), hesperetin (5), and hesperidin (6) used in this study were flavonoids having a phenylchroman skeleton as the basic structure. Antioxidant ability, skin-whitening effect, and histamine-release suppressing effect were examined as their new physiological activities in this study. As a result, in DPPH radical scavenging effect test, which evaluates activity of antioxidant ability, high scavenging effect (90-96％) was observed in (1), (2), and (4). In skin-whitening effect test, it was clarified that (1) and (2) exert higher tyrosinase inhibition activity (42-60) than that of commercially available arbutin (7.3). In toxicity test using human alveolar epithelial cells (in vitro), meanwhile, no difference from control was observe in (3), (4), (5), and (6) at 100 μM concentration, and it was reasoned that there are no considerable toxicity.
〈Original Papers〉Physiological Activities of Several Different Types of Flavonoids
AN00063799-20121220-0007.pdf
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