Kinki University
Kinki University
Kinki University
Kinki University
Kinki University
Kinki University
Kinki University
Kinki University
Kinki University
Kinki University
研究成果の概要（和文）：高齢者の誤嚥は、咳および嚥下反射を制御するサブスタンスP（SP）の分泌低下が原因である。そこで、高齢者に多く、術後に誤嚥のリスクの高い食道癌手術患者における術前後の血中SP 値の推移を調べ、誤嚥発症との関連を検討した。術前後で有意な変動は見られなかったが、術前より低値を示す症例は有意に誤嚥を発症する率が高く（p＝0.004）、術前血中SP 低値（60pg/ml 以下）の症例は術後誤嚥発症のハイリスク群と考えられた。 研究成果の概要（英文）：Aspiration of elderly patients is caused by decreased secretion of substance P (SP) that regulates cough and swallowing reflexes. We prospectively investigated the change of perioperative plasma SP concentration in patients with esophageal cancer undergoing esophagectomy and examined the association with development of aspiration. The plasma SP concentration did not show a significant change in the perioperative period. However, decreased preoperative SP concentration had a strong association with postoperative aspiration (p=0.004), suggesting that patients with decreased preoperative plasma SP concentration (60 pg/ml or less) might carry a higher risk of development of postoperative aspiration in patients after esophagectomy.
サブスタンスPの分泌制御による食道癌術後の誤嚥性肺炎の予防と嚥下機能改善
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