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〈ノート〉可溶化へスぺリジンによるリウマチモデルマウスの症状改善作⽤
https://kindai.repo.nii.ac.jp/records/20939
https://kindai.repo.nii.ac.jp/records/209395f594620-eccc-4009-9a8e-27ad2c66249b
名前 / ファイル | ライセンス | アクション |
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AN00064044-20200331-0024.pdf (593.7 kB)
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Item type | ☆紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2020-06-19 | |||||
タイトル | ||||||
タイトル | 〈ノート〉可溶化へスぺリジンによるリウマチモデルマウスの症状改善作⽤ | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | 〈Notes〉Effect of hesperidin solubilized with its glucoside on improvement of rheumatoid arthritis in mice. | |||||
著者 |
⽶⾕, 俊
× ⽶⾕, 俊× 川⼝, 基⼀郎× 熊沢, 義雄 |
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言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題 | α-glucosylhesperidin, hesperidin, rheumatoid arthritis, solubilization, transglycosylation | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者(英) | ||||||
en | ||||||
Kometani,Takashi | ||||||
著者(英) | ||||||
en | ||||||
Kawaguchi,Kiichirou | ||||||
著者(英) | ||||||
en | ||||||
Kumazawa,Yoshio | ||||||
著者 所属 | ||||||
近畿⼤学農学部⾷品栄養学科: 近畿⼤学アグリ技術⾰新研究所: 近畿⼤学アンチエイジングセンター | ||||||
著者 所属 | ||||||
いわき明星⼤学; 名誉教授 | ||||||
著者 所属 | ||||||
株式会社Vino Science Japan: 北⾥⼤学; 元教授 | ||||||
著者所属(翻訳) | ||||||
Department of Food Science and Nutrition, Faculty of Agriculture, Kindai University: Agricultural Technology and Innovation Research Institute, Kindai University: Anti-Aging Center, Kindai University | ||||||
著者所属(翻訳) | ||||||
Iwaki Meisei University; professor emeritus | ||||||
著者所属(翻訳) | ||||||
Vino Science Japan Co. Ltd.,: Kitasato Univversity; Former professor | ||||||
版 | ||||||
出版タイプ | NA | |||||
出版タイプResource | http://purl.org/coar/version/c_be7fb7dd8ff6fe43 | |||||
出版者 名前 | ||||||
出版者 | 近畿大学農学部 | |||||
書誌情報 |
近畿大学農学部紀要 en : MEMOIRS OF THE FACULTY OF AGRICULTURE OF KINDAI UNIVERSITY 号 53, p. 24-33, 発行日 2020-03-31 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 21896267 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | [Synopsis] Since the functionalities of foods were first advocated from Japan in the 1980s, enormous research has been carried out for about 40 years. As a result, a great deal of research results have been obtained, and many have been put into practical use by utilizing the system of functional foods with health claim. However, the discovery of a novel bioactive substance from nature is considered to have been reaching its limit. The purpose of this study was to examine whether a novel solubilized compound, which has not been utilized due to their low solubility and poor bioavailability, could be available. α-Glucosylhesperidin (enzymatically glucosylated hesperidin; Hsp-G) has a micelle-like structure in an aqueous solution, and may be solubilized by incorporating a poorly soluble compound into its hydrophobic central part. Therefore, hesperidin (Hsp), which is hardly soluble in water, was solubilized with Hsp-G and orally administered to mouse models of rheumatoid arthritis. As a result, Hsp solubilized with Hsp-G was able to improve rheumatic symptoms even at a concentration at which no physiological activity was exhibited by Hsp or Hsp-G alone. Thus, bioactive substances solubilized with Hsp-G may be a practical applicability such as diet supplement in the future. | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf |