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〈論文・報告〉miRNA様siRNAによる遺伝子サイレンシング効果
https://doi.org/10.15100/0000018242
https://doi.org/10.15100/0000018242835cd680-f0ba-4694-924b-124199d8f37a
名前 / ファイル | ライセンス | アクション |
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AA12013209-20161215-0001.pdf (1.0 MB)
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Item type | ☆紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2017-01-13 | |||||
タイトル | ||||||
言語 | ja | |||||
タイトル | 〈論文・報告〉miRNA様siRNAによる遺伝子サイレンシング効果 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Gene Silencing by miRNA-like siRNA | |||||
著者 |
新貝, 恭広
× 新貝, 恭広× 柏原, 慎一× 藤井, 啓史× 峰松, 剛× 吉永, 尚平× 苗村, 円佳× 神武, 洋二郎× 藤井, 政幸 |
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言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題 | RNA interference, siRNA, miRNA, mismatch, DICER, hAgo1, hAgo2, RISC | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
ID登録 | ||||||
ID登録 | 10.15100/0000018242 | |||||
ID登録タイプ | JaLC | |||||
著者 所属 | ||||||
近畿大学大学院産業理工学研究科産業理工学専攻 | ||||||
著者 所属 | ||||||
近畿大学大学院産業理工学研究科産業理工学専攻 | ||||||
著者 所属 | ||||||
近畿大学大学院産業理工学研究科産業理工学専攻 | ||||||
著者 所属 | ||||||
近畿大学大学院産業理工学研究科産業理工学専攻 | ||||||
著者 所属 | ||||||
近畿大学産業理工学部生物環境化学科 | ||||||
著者 所属 | ||||||
近畿大学大学院産業理工学研究科産業理工学専攻 | ||||||
著者 所属 | ||||||
近畿大学産業理工学部生物環境化学科; 准教授 | ||||||
著者 所属 | ||||||
近畿大学産業理工学部生物環境化学科; 教授 | ||||||
版 | ||||||
出版タイプ | NA | |||||
出版タイプResource | http://purl.org/coar/version/c_be7fb7dd8ff6fe43 | |||||
出版者 名前 | ||||||
出版者 | 近畿大学産業理工学部 | |||||
書誌情報 |
ja : かやのもり:近畿大学産業理工学部研究報告 en : Reports of Faculty of Humanity-Oriented Science and Engineering, Kindai University 号 25, p. 1-6, 発行日 2016-12-15 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13495801 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | RNA interference (RNAi) is a genetic regulation system induced by small RNAs. There are two pathways in RNAi, one is induced by small interfering RNA (siRNA) and the other by micro RNA (miRNA). siRNA is a full matched 21-23nt dsRNA and thought to evolutionally develop as a biological defense mechanism against RNA viruses. On the other hand, miRNA is an endogenously transcribed 20-25nt dsRNA having two or three mismatches and is involved in various biological processes. Based on structural and mechanistic similarities and differences between siRNA and miRNA, RNAi efficiencies of siRNAs with 3 mismatches at 2, 10 and 14 positions and siRNAs with 2 mismatches at 2 and 14 positions were evaluated. As a result, siRNA bearing a mismatch at central position showed weaker RNAi effect than siRNAs with no mismatch at central position. It can be concluded that RNAi by Ago2-RISC is stronger than that by Ago1-RISC. | |||||
言語 | en | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf |