研究成果の概要（和文): 研究目的: COPD患者における労作時呼吸困難に関連する脳領域を同定する. 研究方法: COPD患者と年齢マッチさせたコントロール患者に対して, 運動負荷を実施しした. その間, 脳活動を光トポグラフィ装置で脳皮質活動を経時的に計測した. 結果: 運動時に脳皮質oxy-Hb濃度が増加したが, 頭頂側頭葉では増加しなかった. 両群ともに労作時呼吸困難は前頭葉領域のoxy-Hb濃度増加と相関していた. 多変量解析においても葉領域oxy-Hb濃度変化は労作時呼吸困難と独立して関連することが分かった. 結論：COPDの労作時呼吸困難は前頭葉領域脳皮質活動と関連していた. 研究成果の概要（英文): Background Exertional dyspnea is the primary symptom that limits exercise for patients with chronic obstructive pulmonary disease (COPD). It is unknown which activated brain area is associated with this symptom in COPD patients. Objectives To investigate the activation of cortical areas in COPD patients associated with dyspnea during exercise. Methods COPD patients and age-matched controls performed mild intensity constant-work rate cycle exercises for 10 minutes while cerebral hemodynamics and oxygenation were measured by near-infrared spectroscopy (NIRS). Results Oxy-Hb concentration was significantly increased in the prefrontal region during exercise in both groups, but not in temporoparietal regions. Dyspnea scores were positively correlated with changes in oxy-Hb concentrations of the prefrontal regions in both groups. Conclusions Exertional dyspnea was related to activation (oxygenation) of the prefrontal cortex in COPD patients and control subjects.
ＣＯＰＤ患者の労作時呼吸困難と脳活動の関係--ｆＭＲＩ及びＮＩＲＳによる検討
KAKEN_23591128seika.pdf
(342.86KB)
